RESEARCH INTERESTS

Chromatin Modification and noncoding RNAs in Gene Regulation, Epigenetics, inflammation, and Human Disease (in vitro, animal models and patient sample)
Functions of histone modifications in gene regulation, stress response, cardiovascular diseases, neurological disease, and cancer.
Discovering novel noncoding RNAs and analyzing their roles in inflammation and human diseases; Developing long noncoding RNA based biomarkers for cancer, cardiovascular diseases,
Tryptophan metabolism in inflammation and metabolic diseases.
Tumor Biology, Angiogenesis, Hypoxia signaling, and Targeted Gene Therapy (Cell culture and mice xenograft models).

Steroid Hormone Signaling, Molecular Endocrinology, Metabolism, and cardiovascular diseases ((in vitro, animal models and patient sample)
Functions of ovarian hormones in hepatic metabolism, cholesterol homeostasis and human diseases. Mechanism of estrogen signaling.
Roles of MLL histone methylases as novel nuclear receptor (NR) coregulators, their functional interaction with NRs during hormone mediated gene activation and alternative splicing.
Endocrine Disrupting Chemical (EDC): Mechanism of actions, detection, quantification and assessing the degree of endocrine disruption.

Drug discovery, Medicinal chemistry and Immunotherapy:
Design, synthesis, and biochemical evaluation of small molecule based anti-inflammatory drugs, neurotransmitters, anti-cancer drugs, and variety of multifunctional molecules.; Immunotherapy.